Metabolism in Vitro of 19-Nortestosterone in Female Rat Liver Homogenate
نویسندگان
چکیده
منابع مشابه
Metabolism in vitro of 19-nortestosterone in female rat liver homogenate.
A study ilz viva of 19-nortestosterone metabolism in the postmenopausal woman has revealed a metabolic pattern of products similar to that obtained after the administration of testosterone (1). In the present investigation the transformation of 19-nortestosterone by female rat liver homogenates was studied. The rate of reduction of ring A by this tissue system appeared to be extremely rapid. Fo...
متن کاملImatinib metabolism and disposition in isolated rat perfused liver
Imatinib is an orally administered tyrosine kinase inhibitor which inhibits the Bcr-Abl protein-tyrosine kinase with high selectivity. Imatinib is rapidly absorbed from the gut, after oral intake and has an almost absolute bioavailability of 98%. The metabolism of imatinib is mediated by the cytochrome P450 (CYP) isoenzymes in the liver and gut wall. CGP74588 is a major active metabolite of ima...
متن کاملIn vitro metabolism of hyperforin in rat liver microsomal systems.
Hyperforin is an important active component of St. John's wort (Hypericum perforatum) that has been suggested to be responsible for the St. John's wort antidepressive effects and herbal-drug interactions. In this study, the in vitro metabolism profile of hyperforin was investigated using liver microsomes from male and female Sprague-Dawley rats, with or without induction by phenobarbital or dex...
متن کاملSequential deiodination of thyroxine in rat liver homogenate.
Rat liver homogenate was incubated at 37 degrees C with thyroxine, 3,3',5-tri-iodothyronine, 3,3',5'-tri-iodothyronine or 3,3'-di-iodothyronine. The degradation or accumulation of these compounds was measured by specific radioimmunoassays. (1) Production of 3,3',5-tri-iodothyronine from thyroxine was highest at pH 6.0--6.5 and was markedly stimulated by the addition of dithiothreitol and effect...
متن کامل5-hydroxytryptamine Metabolism by the Nuclear Fraction of Rat-liver Homogenate.
1. The metabolism of 5-hydroxy[1'-(14)C]tryptamine creatinine sulphate in the nuclear fraction of rat-liver homogenate was studied. In the incubation mixture five metabolites were found. 2. Two metabolites were not radioactive; one of them was identified as 5-hydroxyindole-3-carboxylic acid and the second tentatively as 5-hydroxyindole-3-aldehyde. 3. 5-Hydroxyindol-3-ylacetic acid, 1'-N-acetyl-...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1960
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)69346-9